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KMID : 0356720040200010057
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Journal of the Korean Society of Coloproctology
2004 Volume.20 No. 1 p.57 ~ p.63
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Clinical Significance of Lymph Node Micrometastasis in Patients with Dukes´ B Colorectal Cancer
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Lee Hyo-Won
Jang Yong-Seog
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Abstract
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Purpose: This study aimed to provide immunohistochemical evidence of micrometastasis in patients with node-negative Dukes´ B colorectal cancer and to evaluate the clinical implications, including prognostic significance, of lymphatic metastasis.
Methods: A retrospective study of 90 patients who underwent a curative operation due to colorectal neoplasms from 1996 to 2001 was performed. Two consecutive sections of lymph nodes were prepared: one for ordinary hematoxylin-eosin staining, and the other for immunohistochemistry with pancytokeratine antibody. All clinical factors, including survival rate, were compared between patients with and without lymph-node metastasis. The mean follow- up period was 36.1 months.
Results: Micrometastasis was confirmed in 115 nodes (7.9%) from 32 patients (35.6%). No correlations were observed between micrometastases and prognostic factors, including survival rate, except for lymphatic invasion and postoperative TNM staging. Twenty-six of the 32 (81.3%) patients with micrometastases belonged to stage T3N0M0 (P＜0.003).
Conclusions: The immunohistochemical assay may be a useful way to identify micrometastasis in patients with Dukes´ B colorectal neoplasms, but we were not able to demonstrate the prognostic significance of micrometastasis. J Korean Soc Coloproctol 2004;20:57-63
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KEYWORD
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Colorectal neoplasms, Dukes´ B, Lymphatic metastasis, Survival rate, Immunohistochemistry
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